1st Edition

Cyclic Nucleotide Signaling




ISBN 9781482235562
Published May 12, 2015 by CRC Press
288 Pages 9 Color & 48 B/W Illustrations

USD $175.00

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Book Description

Showcasing the recent progresses of the field, Cyclic Nucleotide Signaling covers the major tools and methodologies used in various areas of research. The majority of the chapters are protocol oriented, with the goal of providing clear directions for laboratory use. Students and investigators new to the field will find this book particularly informative, as will scientists already actively researching nucleotide signaling.

Table of Contents

Compartmentalization of cyclic nucleotide signaling
Analysis of EPAC-mediated cAMP functions in cell communication
Cyclic nucleotide analogs as pharmacological tools for studying signaling pathways
Discovery of small molecule EPAC specific modulators
Adenylyl cyclase and A kinase-anchoring proteins in cardiovascular physiology and pathology
Cyclic nucleotide recognition and selectivity
Real-time intracellular imaging of cGMP
Dissecting cyclic nucleotide signalosomes by chemical proteomics
Cyclic nucleotide analogs as chemical tools for interaction analyses
cAMP signaling in pancreatic β cells
Quantitative high throughput cAMP assay for G-protein coupled receptors
Quantitative proteomics analysis of the cAMP signaling pathway
Network analysis of cyclic nucleotide signaling
Evolution and functional diversity of cyclic nucleotide binding domains
X-ray crystallographic analysis of cyclic nucleotide activated protein kinases
Dissect physiological functions of PKA isoforms using genetically modified mouse models
Assessing cyclic nucleotide binding domain allostery by NMR analysis
Fluorescence resonance energy transfer (FRET) imaging of cyclic nucleotide in live cells
Structural and functional analyses of exchange protein directly activated by cAMP
Structural analysis of PKA: strategies for therapeutic intervention
Monitoring cyclic nucleotide signaling using genetically encoded fluorescent reporters

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Editor(s)

Biography

Cheng, Xiaodong