Located at the interface between blood and the brain, the blood-brain barrier is a dynamic permeability barrier formed by a continuous layer of specialized endothelial cells endowed with important permeability, transport, and regulatory functions that both protect the internal milieu of the brain and allow essential nutrients to be transported into the brain. Over the last 25 years, we have witnessed remarkable expansion of our knowledge of the structure, biology, and function of the cerebral endothelium.
In The Blood-Brain Barrier in Health and Disease, Volume 1, international experts discuss basic and new concepts and most recent advances pertaining to the development of the cerebral microvascular system. Subjects include the structure, function, permeability properties, transport mechanisms, and the inherent heterogeneity of the cerebral endothelium; the anatomy and physiological properties of the neurovascular unit; functional aspects of the choroid plexus; and important concepts and advances made over the last two decades that have shaped our understanding of the immunological function of the blood-brain barrier.
This book is intended to serve as a valuable source of basic and advanced information for researchers, students, and clinicians interested in this fast-expanding field and stimulate further research well into the future.
Table of Contents
Morphological and Functional Properties of the Blood-Brain Barrier
Katerina Dorovini-Zis and Sukriti Nag
The Human Cerebral Cortex Microvascular System: Development and Composition of the Meningeal and Intracerebral Extrinsic and Intrinsic (Blood-Brain Barrier) Compartments
Heterogeneity of the CNS Microvascular Endothelium
Joel S. Pachter, Debayon Paul, Shujun Ge
The Neurovascular Unit
Martha E. O’Donnell
The Elusive Multipotent Microvascular Pericyte
Paula Dore-Duffy, Nilufer Esen, Zakhar Serkin
Fluid-Forming Function of the Choroid Plexus: What is the Role of Aquaporin-1?
Conrad E. Johanson
The Expression and Function of ABC Transporters at the Blood-Brain Barrier
Wandong Zhang, Michelle Bamji-Mirza, Nina Chang, Arsalan S. Haqqani and Danica B. Stanimirovic
The Blood-Brain Barrier and the Immune Privilege of the Central Nervous System
Benjamin D. Clarkson, Melissa G. Harris, Aditya Rayasam and Zsuzsanna Fabry
Inflammatory Mediators and the Blood-Brain Barrier
Katerina Dorovini-Zis and Alexander Easton
Endothelial Surface-Associated Molecules of Relevance to the Immune Function of the Blood-Brain Barrier
Chemokines as Mediators of Leukocyte Trafficking and Activation at the Blood-Brain Barrier
Jacqueline Quandt and Katerina Dorovini-Zis
Leukocyte Entry into the Brain
Katerina Dorovini-Zis, Donald Wong, Kenneth Liu